Ampa One TMS in San Francisco | One-Day TMS Program for Depression

Q: What is the One-Day TMS Program in San Francisco?

It is an accelerated form of TMS that delivers multiple iTBS sessions in a single day, rather than weeks of daily visits. Sessions are spaced through the day with rest periods in between, and patients return home the same day. Schedules vary by patient and are determined by your clinician.

Drug-free treatment, in the Presidio

For many San Franciscans, the answer isn't another prescription. Transcranial Magnetic Stimulation (TMS) is an FDA-cleared, non-invasive treatment that uses magnetic pulses to stimulate the brain's mood-regulating circuits — with no anesthesia and no downtime. My primary TMS system is Ampa One, an FDA-cleared system featuring a camera-enabled coil for precise, repeatable positioning.

What makes it different here: I don't run a TMS mill. Treatment is delivered as one part of a complete, integrative psychiatric relationship — woven together with therapy, metabolic care, and lifestyle work so the gains actually hold.

The One-Day TMS Program

A standard course of TMS means daily visits, five days a week, for several weeks — about 36 sessions. The One-Day TMS Program compresses that into a single, structured day: brief (about three-minute) intermittent theta-burst (iTBS) sessions, spaced through the day with rest periods, and home the same evening.

In the ONE-D open-label case series (n=32), 87.5% of patients responded and 71.2% reached remission at six weeks; a propensity-matched comparison found single-day remission of 49% versus 25% for a traditional 36-day course. These are early findings from small samples, and individual results may vary. See the research and full overview →

What it can help

Treatment-resistant depression (the FDA-cleared indication for Ampa One)
Major depressive disorder
A drug-free or medication-sparing path when medications haven't worked or aren't tolerated

My practice is also actively following and investigating emerging, accelerated protocols for anxiety, OCD, and addiction — investigational and, where applicable, off-label uses that are not FDA-cleared. Explore the frontier →

What to expect

After a thorough evaluation, your care team calibrates a safe, personalized level of stimulation. Treatment is a structured, comfortable, fully supervised course — in-office at the Presidio. Read the full neuromodulation overview →

Your Physician

One physician. The full spectrum of you.

Dr. Raghu Appasani is a board-certified psychiatrist, fellowship-trained in addiction psychiatry and integrative-medicine focused — one of the very few physicians who hold the entire spectrum of mental health in a single, integrated relationship.

Board-Certified Psychiatrist · ABPNFellowship-Trained · Addiction PsychiatryIntegrative MedicineKeck School of MedicineUCSF

More about Dr. Appasani →

Questions

Good to know.

Where do you offer TMS in San Francisco? +

In-person at my Presidio practice in San Francisco, on the FDA-cleared Ampa One system. The exact suite is shared upon confirmation, for discretion.

What is the One-Day TMS Program? +

An accelerated form of TMS that delivers multiple iTBS sessions in a single day rather than weeks of daily visits. Sessions are spaced through the day with rest periods in between, and patients return home the same day. Schedules vary by patient and are determined by your clinician.

Is Ampa One FDA-cleared? +

Yes. Ampa One is an FDA-cleared TMS system, cleared for the treatment of treatment-resistant depression by prescription only.

How effective is single-day TMS? +

In the ONE-D open-label case series (Vaughn et al., 2025, n=32), 87.5% of patients responded and 71.2% achieved remission at six weeks; a propensity-matched comparison (Berlow et al., 2026) found single-day remission of 49% versus 25% for a 36-day course. These are early findings from small samples and individual results may vary. See the research →

How is this different from other TMS providers? +

Most TMS is delivered in isolation. Here it is integrated with therapy, metabolic and nutritional care, and lifestyle work as part of one concierge psychiatric relationship — so the change lasts.

Ampa One TMS & the One-Day Program in San Francisco.